Norman Worthington has founded or co-founded more than a dozen companies. An early venture was Software Toolworks, one of the first highly successful consumer software companies, which created several all-time best-selling titles, including Mavis Beacon Teaches Typing! and the Chessmaster series.

In 1993, Worthington entered a joint venture with Computer Associates (CA), to launch the world's first Enterprise Application Integration system. Called Opal, it integrated the back office systems of Fortune 1000 companies and made the information accessible over the Internet. It was used by Wal-Mart, among many others, as the backbone of their supply-chain extension strategy in the late 90s. In 1996, CA purchased Worthington's interest in the joint venture.

In 2006, Worthington founded Star2Star Communications. A global leader in cloud-native communications, Star2Star unifies customers' voice, video, fax, instant messaging and presence management into a single, easy-to-use system that overcomes the reliability and quality limitations of other Internet communications technologies. In March 2021, in a $437 million transaction, Star2Star was acquired by Sangoma Technologies Corporation. Worthington became Chairman of the Board of the combined company.

Worthington received his bachelor of arts with a concentration in economics from New College of Florida and law degree from Northwestern School of Law, Lewis & Clark College.

He lives in Sarasota with Susan, his wife of over thirty years. Together, they have an adult daughter and son. Worthington is an avid pilot, yachtsman, and fly fisherman and has an unjustifiably large collection of bicycles which he uses most days of the week.