Martine Rothblatt is the Founder, CEO, and Chairwoman of United Therapeutics and "trans-everything" pioneer of satellite communications and biotechnology. In 1990, she co-founded what is now Sirius XM, the first satellite-to-car broadcasting company, but switched to biotech a few years later after her five-year-old daughter, Jenesis, was diagnosed with pulmonary arterial hypertension and given two to three years to live. Martine devoted herself to curing this fatal disease, and she succeeded. Today, Jenesis is alive and well, and United Therapeutics—the company Martine founded and runs—offers five FDA-approved drugs, four for pulmonary arterial hypertension and one for neuroblastoma. "I'm a person who likes to hear why something can't be done," she says, "and I'll whittle down every one of the can'ts one at a time." She is also a pioneer of pig cloning with the goal of achieving lung transplants that the human body doesn't reject. United Therapeutics' pig "pharm" in Blacksburg, Virginia, is the world's largest cloner of pigs. Martine is now the highest-paid pharmaceutical CEO, the highest-paid female CEO, and the highest-paid transgender CEO. She is fond of the prefix "trans" because her goal is to transcend all limitations the world seems to impose on us. She was originally known as Martin, and in 1994 underwent sex reassignment surgery. She calls herself a transhumanist, a Kurzweilian proponent of the ethical merging of human beings and technology so that people can defy disease and death. An advocate of employing nano and cybernetic technology to extend human life, she had engineers build a robot called Bina48, a likeness of her wife Bina at the age of 48. She envisions a time when everyone will upload their brains to computers so that their minds can live forever.